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What is REVEL?

REVEL is an ensemble method for predicting the pathogenicity of missense variants based on a combination of scores from 13 individual tools. The dataset of REVEL scores was calculated in 2016 and has not been updated since then.

Tools used to create prediction scores:

  • MutPred
  • FATHMM v2.3
  • VEST 3.0
  • PolyPhen-2
  • SIFT
  • PROVEAN
  • MutationAssessor
  • MutationTaster
  • LRT
  • GERP++
  • SiPhy
  • phyloP
  • phastCons

How to Use REVEL Scores

A REVEL score higher than 0.5 predicts that the variant is likely to cause a harmful effect on the protein. The higher the score, the more likely the harmful effect.

Additional Reading

Original paper: "REVEL: An Ensemble Method for Predicting the Pathogenicity of Rare Missense Variants"