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Cross-Link

A cross-link is a special connection between two parts of a protein or between two different proteins. This helps stabilize the protein's structure or join proteins together for a specific function.

Example

In collagen (a protein in skin and bones), cross-links between protein chains make the structure strong and resilient.

  • Covalent cross-links - Permanent chemical bonds
  • Non-covalent cross-links - Weaker, reversible interactions
  • Intermolecular cross-links - Between different protein molecules
  • Intramolecular cross-links - Within the same protein molecule

Clinical Significance

Variants affecting cross-links can: - Destabilize protein structure - Disrupt protein complexes - Affect tissue strength and integrity - Impact protein folding